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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DGKH
All Species:
16.36
Human Site:
S588
Identified Species:
45
UniProt:
Q86XP1
Number Species:
8
Phosphosite Substitution
Charge Score:
0.13
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q86XP1
NP_690874.2
1220
134866
S588
E
D
A
V
E
S
S
S
E
E
S
L
G
E
S
Chimpanzee
Pan troglodytes
XP_001151474
1220
134870
S588
E
D
A
V
E
S
S
S
E
E
S
L
G
E
S
Rhesus Macaque
Macaca mulatta
XP_001114920
1167
129871
S536
E
A
E
D
G
D
G
S
G
S
V
C
G
S
T
Dog
Lupus familis
XP_534133
1182
132580
S550
E
D
T
V
E
S
S
S
E
E
S
L
C
E
S
Cat
Felis silvestris
Mouse
Mus musculus
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507672
1254
138458
S619
E
E
P
G
D
F
S
S
E
D
S
S
L
T
D
Chicken
Gallus gallus
XP_001232791
1333
149344
S696
E
E
G
E
E
F
S
S
E
E
S
L
S
E
S
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001108193
586
65385
E18
V
Q
S
R
E
H
Y
E
T
A
Q
F
N
V
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
A8JQ65
1895
211641
L609
T
P
G
S
N
A
Y
L
L
N
P
N
I
S
I
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001202627
1158
127377
S518
M
M
G
P
S
T
S
S
R
V
F
K
P
R
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
62.2
90.7
N.A.
N.A.
N.A.
N.A.
82.3
76.8
N.A.
39
N.A.
34.9
N.A.
N.A.
51.5
Protein Similarity:
100
99.8
73.4
92.8
N.A.
N.A.
N.A.
N.A.
88.1
82.9
N.A.
43.2
N.A.
46.5
N.A.
N.A.
64.1
P-Site Identity:
100
100
20
86.6
N.A.
N.A.
N.A.
N.A.
33.3
66.6
N.A.
6.6
N.A.
0
N.A.
N.A.
13.3
P-Site Similarity:
100
100
26.6
86.6
N.A.
N.A.
N.A.
N.A.
53.3
73.3
N.A.
13.3
N.A.
6.6
N.A.
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
12
23
0
0
12
0
0
0
12
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
12
12
0
0
% C
% Asp:
0
34
0
12
12
12
0
0
0
12
0
0
0
0
23
% D
% Glu:
67
23
12
12
56
0
0
12
56
45
0
0
0
45
12
% E
% Phe:
0
0
0
0
0
23
0
0
0
0
12
12
0
0
0
% F
% Gly:
0
0
34
12
12
0
12
0
12
0
0
0
34
0
0
% G
% His:
0
0
0
0
0
12
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
12
0
12
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
12
0
0
0
% K
% Leu:
0
0
0
0
0
0
0
12
12
0
0
45
12
0
0
% L
% Met:
12
12
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
12
0
0
0
0
12
0
12
12
0
0
% N
% Pro:
0
12
12
12
0
0
0
0
0
0
12
0
12
0
0
% P
% Gln:
0
12
0
0
0
0
0
0
0
0
12
0
0
0
0
% Q
% Arg:
0
0
0
12
0
0
0
0
12
0
0
0
0
12
0
% R
% Ser:
0
0
12
12
12
34
67
78
0
12
56
12
12
23
45
% S
% Thr:
12
0
12
0
0
12
0
0
12
0
0
0
0
12
12
% T
% Val:
12
0
0
34
0
0
0
0
0
12
12
0
0
12
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
23
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _